Chapter 1 Introduction to Immunity and the Immune System

Multiple Choice
Identify the choice that best completes the statement or answers the question.

____	1.	The scientist known for his use of attenuated vaccines and as the father of immunology is:
a.	Edward Jenner.	c.	Louis Pasteur.	
b.	Elie Metchnikoff.	d.	Emil von Behring.	

____	2.	The field of immunology can be credited for its contributions to the development of:
a.	bacterial identification.	c.	surgery.	
b.	vaccines.	d.	phlebotomy.	

____	3.	The ancient practice of inhaling powder from smallpox scabs is an early version of:
a.	cross reactivity.	c.	susceptibility.	
b.	attenuated vaccination.	d.	cell identification.	

____	4.	Attenuation can take place through ______ a pathogen.
a.	Freezing	c.	Aging	
b.	Growing	d.	Flooding	

____	5.	Humoral immunity was considered the most important aspect of immunity for a time in history because of the work of _____________, who received the Nobel Prize in Physiology for his work in serum therapy.
a.	Louis Pasteur	c.	Almroth Wright	
b.	Emil von Behring	d.	Edward Jenner	

____	6.	The discovery of _______ helped bring the importance of cellular immunity to light.
a.	Antibodies	c.	Opsonins	
b.	Phagocytosis	d.	Bacterial toxin neutralization by serum	

____	7.	Phagocytosis is appropriately categorized into which of the following?
a.	Adaptive immunity	c.	Humoral immunity	
b.	Innate immunity	d.	Specific immunity	

____	8.	A patient with a viral infection that has initiated their cell-mediated immunity might have an increased number of which leukocytes in their peripheral blood?
a.	Lymphocytes	c.	Monocytes	
b.	Neutrophils	d.	Basophils	

____	9.	Which of the following cells can phagocytize foreign microbes?
a.	T lymphocytes	c.	Macrophages	
b.	B lymphocytes	d.	Natural killer (NK) cells	

____	10.	Which of the following cells is a phagocytic cell that has a similar morphology to nerve cells?
a.	Neutrophils	c.	Mast cells	
b.	Dendritic cells	d.	Macrophages	

____	11.	Macrophages play a key role in adaptive immunity through which function?
a.	Phagocytosis	
b.	Anti-tumor activity	
c.	Presenting phagocytosed microbes to T lymphocytes	
d.	Microbial killing	

____	12.	Which is a key antigen-presenting cell found in the digestive tract?
a.	Basophil	c.	Dendritic cell	
b.	Macrophage	d.	Mast cell	

____	13.	Maturation and differentiation of important immune cells happens within the: 
a.	blood.	c.	lymph nodes.	
b.	bone marrow.	d.	spleen.	

____	14.	A patient with a weakened immune response may need to have which primary lymphoid tissue examined?
a.	Spleen	c.	Thymus	
b.	Mucosal associated lymphoid tissue (MAST)	d.	Lymph nodes	

____	15.	Lymphocytes come in contact with foreign antigens and activate the adaptive immune system in which lymphoid tissue?
a.	Bone marrow	c.	Thymus	
b.	Peripheral blood	d.	Cutaneous-associated lymphoid tissue (CALT)	

____	16.	Which lymphoid tissue can protect us against pathogens we eat?
a.	MALT	c.	Lymph nodes	
b.	CALT	d.	Spleen	

____	17.	Secondary lymphoid tissues that are located near our joints and serve as a collecting duct for lymph fluid are:
a.	spleen cells.	c.	MALT.	
b.	lymph nodes.	d.	CALT.	

____	18.	Foreign microbes that enter through a cut in our hand should expect defense from which lymphoid tissue?
a.	CALT	c.	MALT	
b.	Spleen	d.	Thymus	

____	19.	Macrophages line the _______ found within the lymph nodes.
a.	Outer cortex	c.	Paracortex	
b.	Inner medulla	d.	Sinuses	

____	20.	B cells activate and generate B-cell memory in the _____ of the lymph nodes. 
a.	Sinuses	c.	Paracortex	
b.	Secondary follicles	d.	Primary follicles	

____	21.	Antigen presentation happens within the ______of the lymph nodes.
a.	Primary follicles	c.	Inner medulla	
b.	Secondary follicles	d.	Sinuses	

____	22.	We can identify cells by proteins found on their cell surfaces. These are known as:
a.	adhesion molecules.	c.	chemotaxins.	
b.	antibodies.	d.	clusters of differentiation.	

____	23.	Which CD marker represents those found on B lymphocytes?
a.	CD4	c.	CD8	
b.	CD20	d.	CD3	

____	24.	A patient with antibodies in their serum to a particular virus has activated which immune cells?
a.	NK cells	c.	B lymphocytes	
b.	Macrophages	d.	T lymphocytes	

____	25.	Humoral immunity is a key function of which cell?
a.	NK cells	c.	Macrophages	
b.	T lymphocytes	d.	B lymphocytes	

____	26.	Which lymphocyte is part of our innate immunity?
a.	CD4 cells	c.	CD19,20 cells	
b.	CD8 cells	d.	NK cells	

____	27.	Our first line of defense against virally infected cells and tumor cells are:
a.	B lymphocytes.	c.	neutrophils.	
b.	T lymphocytes.	d.	NK cells.	

Chapter 1 Introduction to Immunity and the Immune System
Answer Section

MULTIPLE CHOICE

	1.	ANS:	C	PTS:	1	OBJ:	1	MSC:	Taxonomy 2

	2.	ANS:	B	PTS:	1	OBJ:	1	MSC:	Taxonomy 1

	3.	ANS:	B	PTS:	1	OBJ:	2	MSC:	Taxonomy 2

	4.	ANS:	C	PTS:	1	OBJ:	1	MSC:	Taxonomy 1

	5.	ANS:	B	PTS:	1	OBJ:	3	MSC:	Taxonomy 1

	6.	ANS:	B	PTS:	1	OBJ:	3	MSC:	Taxonomy 2

	7.	ANS:	B	PTS:	1	OBJ:	4	MSC:	Taxonomy 2

	8.	ANS:	A	PTS:	1	OBJ:	4	MSC:	Taxonomy 3

	9.	ANS:	C	PTS:	1	OBJ:	5	MSC:	Taxonomy 1

	10.	ANS:	B	PTS:	1	OBJ:	5	MSC:	Taxonomy 1

	11.	ANS:	C	PTS:	1	OBJ:	6	MSC:	Taxonomy 2

	12.	ANS:	D	PTS:	1	OBJ:	6	MSC:	Taxonomy 1

	13.	ANS:	B	PTS:	1	OBJ:	7	MSC:	Taxonomy 1

	14.	ANS:	C	PTS:	1	OBJ:	7 & 8	MSC:	Taxonomy 3

	15.	ANS:	D	PTS:	1	OBJ:	7 & 8	MSC:	Taxonomy 3

	16.	ANS:	A	PTS:	1	OBJ:	8	MSC:	Taxonomy 3

	17.	ANS:	B	PTS:	1	OBJ:	8 & 9	MSC:	Taxonomy 1

	18.	ANS:	A	PTS:	1	OBJ:	8	MSC:	Taxonomy 3

	19.	ANS:	D	PTS:	1	OBJ:	9	MSC:	Taxonomy 1

	20.	ANS:	B	PTS:	1	OBJ:	9 & 10	MSC:	Taxonomy 2

	21.	ANS:	A	PTS:	1	OBJ:	9 & 10	MSC:	Taxonomy 2

	22.	ANS:	D	PTS:	1	OBJ:	11	MSC:	Taxonomy 1

	23.	ANS:	B	PTS:	1	OBJ:	11	MSC:	Taxonomy 1

	24.	ANS:	C	PTS:	1	OBJ:	12	MSC:	Taxonomy 3

	25.	ANS:	D	PTS:	1	OBJ:	12	MSC:	Taxonomy 2

	26.	ANS:	D	PTS:	1	OBJ:	4, 11, & 13	MSC:	Taxonomy 2

	27.	ANS:	D	PTS:	1	OBJ:	13	MSC:	Taxonomy 2