Chapter 01: Cell Pathology
Damjanov: Pathology for the Health Professions, 6th Edition

MULTIPLE CHOICE

	1.	Which of the following is a nuclear sign of irreversible cell injury?
a.	Dysplasia	
b.	Pyknosis	
c.	Hydropic change	
d.	Vacuolar degeneration	

ANS:	B	DIF:	1	REF:	p. 10	OBJ:	5

	2.	The inhibition of ATP production caused by hypoxia will result in which cellular outcome?
a.	Increased ribosome production	
b.	Dilation and fragmentation of the rough endoplasmic reticulum	
c.	Mitochondrial multiplication	
d.	Increased alkalinity of the hyaloplasm	

ANS:	B	DIF:	1	REF:	p. 8	OBJ:	4

	3.	Which of the following is an oxygen radical?
a.	Hydrogen peroxide	
b.	Acid hydrolase	
c.	Carbon tetrachloride	
d.	Lipofuscin	

ANS:	A	DIF:	2	REF:	p. 11	OBJ:	6

	4.	Which of the following organs undergoes physiological atrophy during childhood and adolescence?
a.	Uterus	
b.	Thymus	
c.	Thyroid	
d.	Adrenals	

ANS:	B	DIF:	2	REF:	p. 13	OBJ:	8

	5.	Enlargement of the heart, caused by hypertension, is a result of which physiologic process?
a.	Hypertrophy	
b.	Atrophy	
c.	Metaplasia	
d.	Dysplasia	

ANS:	A	DIF:	2	REF:	p. 13	OBJ:	9

	6.	When irritated by chronic exposure to cigarette smoke, columnar bronchial epithelium changes into stratified squamous epithelium. What is this physiologic change an example of?
a.	Hypertrophy	
b.	Hyperplasia	
c.	Atrophy	
d.	Metaplasia	

ANS:	D	DIF:	3	REF:	p. 14	OBJ:	10

	7.	Chronic hemolysis of red blood cells is characterized by accumulation of an iron-containing brown pigment in the cytoplasm of liver cells. What is this brown pigment called?
a.	Melanin	
b.	Tyrosine	
c.	Hemosiderin	
d.	Bilirubin	

ANS:	C	DIF:	3	REF:	p. 15	OBJ:	11

	8.	Which type of necrosis is found in the granulomas of pulmonary tuberculosis?
a.	Coagulation necrosis	
b.	Liquefactive necrosis	
c.	Caseous necrosis	
d.	Fibrinoid necrosis	

ANS:	C	DIF:	3	REF:	p. 17	OBJ:	15

	9.	What type of irreversible cell injury is seen in myocardial infarction?
a.	Dystrophic calcification	
b.	Metastatic calcification	
c.	Fibrinoid necrosis	
d.	Coagulation necrosis	

ANS:	D	DIF:	3	REF:	p. 17	OBJ:	15

	10.	Liquefactive necrosis caused by infarction is typically seen in which organ?
a.	Heart	
b.	Brain	
c.	Liver	
d.	Kidney	

ANS:	B	DIF:	3	REF:	p. 17	OBJ:	15

	11.	What best describes hydropic change at the cellular level?
a.	An equal level of water inside and outside the cell	
b.	A decrease of water in the cytoplasm	
c.	An increase of water in the cytoplasm	
d.	A result of irreversible cell injury	

ANS:	C	DIF:	2	REF:	p. 8	OBJ:	5

	12.	Minerals like copper and zinc play what role in cellular function?
a.	They assist maintaining cytoplasm homeostasis.	
b.	They assist in the removal of cellular waste products.	
c.	They are necessary for ATP production.	
d.	They enable several important enzymes to function.	

ANS:	D	DIF:	1	REF:	p. 8	OBJ:	2

	13.	Which of the following would not be considered a pathogenetic mechanism for causing cellular injury?
a.	Toxins	
b.	Microbial pathogens	
c.	Genetic disturbances	
d.	Coagulation	

ANS:	D	DIF:	2	REF:	p. 7	OBJ:	6

	14.	Which statement best describes a fatty liver?
a.	There is an extracellular accumulation of intermediate metabolites.	
b.	There is an intracellular accumulation of triglycerides.	
c.	There is intracellular accumulation of sodium in the liver.	
d.	There is extracellular accumulation of sodium in the liver.	

ANS:	B	DIF:	3	REF:	p. 15	OBJ:	12

	15.	Metastatic calcification occurs most likely in which organ?
a.	Heart	
b.	Brain	
c.	Pancreas	
d.	Kidney	

ANS:	D	DIF:	3	REF:	p. 18	OBJ:	16